摘要
A new Schiff base compound, 2-hydroxybenzoic acid [1-（3,5-dibromo-2-hydroxyphenyl） methylidene]hydrazide methanol （C14H10Br2N2O3·CH3OH）, has been synthesized by the condensation of equimolar 3,5-dibromosalicylaldehyde and 2-hydroxybenzoic acid hydrazide in a methanol solution. The compound was characterized by elemental analysis, IR spectra, and singlecrystal X-ray diffraction. The compound consists of a Schiff base moiety 2-hydroxybenzoic acid [1-（3,5-dibromo-2-hydroxyphenyl）methylidene]hydrazide and a lattice methanol molecule. The crystal belongs to the monoclinic system, space group P21/n with a = 7.183（1）, b = 15.673（2）, c = 15.001（2） A, β = 98.345（2）°, Z = 4, V = 1670.9（4） A^3, Dc = 1.773 g/cm^3, Mr = 446.10, λ（MoKα） = 0.71073 , μ = 4.872 mm^-1, F（000） = 880, R = 0.0458 and wR = 0.0963. A total of 3445 unique reflections were collected, of which 2236 with I 〉 2σ（Ⅰ） were observed. As expected, the molecule adopts a trans configuration about the C=N double bond. The two benzene rings are nearly coplanar （mean deviation from the combined plane is 0.061（4） ）, with the dihedral angle of 7.9（3）°. The preliminary biological tests show that the compound has moderate antibacterial activities.
A new Schiff base compound, 2-hydroxybenzoic acid [1-（3,5-dibromo-2-hydroxyphenyl） methylidene]hydrazide methanol （C14H10Br2N2O3·CH3OH）, has been synthesized by the condensation of equimolar 3,5-dibromosalicylaldehyde and 2-hydroxybenzoic acid hydrazide in a methanol solution. The compound was characterized by elemental analysis, IR spectra, and singlecrystal X-ray diffraction. The compound consists of a Schiff base moiety 2-hydroxybenzoic acid [1-（3,5-dibromo-2-hydroxyphenyl）methylidene]hydrazide and a lattice methanol molecule. The crystal belongs to the monoclinic system, space group P21/n with a = 7.183（1）, b = 15.673（2）, c = 15.001（2） A, β = 98.345（2）°, Z = 4, V = 1670.9（4） A^3, Dc = 1.773 g/cm^3, Mr = 446.10, λ（MoKα） = 0.71073 , μ = 4.872 mm^-1, F（000） = 880, R = 0.0458 and wR = 0.0963. A total of 3445 unique reflections were collected, of which 2236 with I 〉 2σ（Ⅰ） were observed. As expected, the molecule adopts a trans configuration about the C=N double bond. The two benzene rings are nearly coplanar （mean deviation from the combined plane is 0.061（4） ）, with the dihedral angle of 7.9（3）°. The preliminary biological tests show that the compound has moderate antibacterial activities.
基金
This work was supported by the Natural Science Foundation of Gansu Province (No. 3ZS061-A25-026)
‘Qing Lan’ Talent Engineering Funds by Lanzhou Jiaotong University
