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OXA-23酶介导的鲍氏不动杆菌对碳青霉烯的耐药机制 被引量：6

Mechanism of Carbapenem-resistance Induced by OXA-23 in Acinetobacter baumannii
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摘要 OXA-23酶是第一个从鲍氏不动杆菌中分离出来的D类碳青霉烯酶,blaOXA-23基因位于质粒或者染色体上。本文主要对鲍氏不动杆菌中OXA-23酶介导的对碳青霉烯类抗生素的耐药机制进行综述,并对编码OXA-23酶基因的结构、遗传背景及流行状况进行总结。 OXA-23 is a carbapenemase of class D that was first isolated from a clinical isolate of Acinetobacter bauamnnii. The gene encoding OXA-23 is located in chromosome or plasmid. In this review, the mechanism of carbapenem-resistance induced by OXA-23 in Acinetobacter baumannii was described. In addition, structure, genetic background and prevalence of the gene encoding OXA-23 were also discussed.
作者 钱洁 宋诗铎
机构地区 天津医科大学第二医院
出处 《国外医药（抗生素分册）》 CAS 2007年第3期121-123,134,共4页 World Notes on Antibiotics
关键词 鲍氏不动杆菌 碳青霉烯酶 插入序列 Acinetobacter baumannii carbapenemase insertion sequence
分类号 R978.1 [医药卫生—药品]
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参考文献13

  • 1Fernandez-Cuenca F,Martinez-Martinez L,Conejo M C,et al.Relationship between beta-lactamase production,outer membrane protein and penicillin-binding protein profiles on the activity of carbapenems against clinical isolates of Acinetobacter baumannii[J].J Antimicrob Chemother,2003,51 (3):565
  • 2Walther-Rasmussen J,Hoiby N.OXA-type carbapenemases[J].J Antimicrob Chemother,2006,57 (3):373
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  • 4Barlow M,Hall B G.Phylogenetic analysis shows that the OXA β-lactamase genes have been on plasmids for millions of years[J].J Mol Evol,2002,55 (3):314
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  • 6Heritier C,Poirel L,Nordmann P.Cephalosporinase overexpression resulting from insertion of ISAbal in Acinetobacter baumannii[J].Clin Microbiol Infect,2006,12 (2):123
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同被引文献62

引证文献6

二级引证文献36

国外医药（抗生素分册）
2007年 第3期

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