摘要
目的评估高血压病患者血管内皮功能状态,并探讨其与血浆中单核细胞趋化蛋白1水平变化的临床意义。方法应用高分辨率B超检测肱动脉血流介导血管舒张功能,采用酶联免疫吸附法检测血浆单核细胞趋化蛋白1、血管性假血友病因子的浓度,硝酸还原酶法间接反应血浆中一氧化氮水平。结果与对照组相比,高血压病患者肱动脉血流介导血管舒张功能(6.6%±2.6%比10.7%±1.8%)和血浆中一氧化氮浓度(16.90±5.49μmol/L比24.55±7.32μmol/L)明显下降(P<0.01);血管性假血友病因子(122.02±63.53ng/L比90.27±38.38ng/L,P<0.01)、单核细胞趋化蛋白1(19.94±8.95ng/L比15.93±6.78ng/L,P<0.05)的浓度升高,单核细胞趋化蛋白1和肱动脉血流介导血管舒张功能呈低度负相关(r=-0.278,P<0.05)。结论高血压病患者存在血管内皮功能不全,可能与单核细胞趋化蛋白1水平升高有关。
Aim To explore the clinical implications between plasma monocyte chemoattractant protein-1 （MCP-1 ） levels and flow-mediated dilation （FMD） of brachial arteries in individuals with essential hypertension. Methods 42 patients with essential hypertension and 40 healthy controls were enrolled in the study. FMD on brachial artery at rest and during reactive hyperemia was assessed by high-resolution, two-dimensional uhrasonography. Plasma MCP-1, nitric oxide （NO） and yon Wille-brand factor （vWF） levels were also determined. Results Compared with controls, brachial artery FMD and NO level of hypertensive patients were significantly decreased （ 6.6% ± 2.6% vs 10.7% ± 1.8%, 16.90 ± 5.49 μmol/L vs 24.55 ± 7.32 μmol/L, P 〈0.01）. Plasma vWF, MCP-1 of hypertensive patients were markedly increased （122.02±63.53 ng/L vs 90.27 ± 38.38ng/L, P〈0.01; 19.94±8.95ng/L vs 15.93±6.78ng/L, P〈0.05）. The levels of MCP-1 were negatively correlated with FMD （ r = - 0.278, P 〈 0.05）. Conclusions Endothelium-dependent vasodilation is impaired in patients with essential hypertension, which is associated with the increased MCP-1 level.
出处
《中国动脉硬化杂志》
CAS
CSCD
2007年第2期125-128,共4页
Chinese Journal of Arteriosclerosis
