摘要
Synthesis of mcrocyclic lactones has been applied to medical and flavor field. Triglycerides(2) of ω-hydroxycarboxylic acids synthesized from malania oleifera chum oil(1) via ozonization and reduction, and compound 2 were catalytically transformed to macrocyctic lactones(3). This is a new method involving fewer steps and a 61% yield of cyclopentadecanolide was obtained. The reactive properties of macrolactonization of ω-hydroxycarboxylic acids were also studied. The result obtained shows that the priority order of macrolactonization as follows: 11-undecalactone>cyclotridecanolide>cyclopentadecanolide, i.e. the short chain ω-hydroxycarboxylic acids were preferentially cyclized.
Synthesis of mcrocyclic lactones has been applied to medical and flavor field. Triglycerides（2） of to-hydroxycarboxylic acids synthesized from malania oleifera chum oil （1） via ozonization and reduction, and compound 2 were catalytically transformed to macrocyctic lactones （3）. This is a new method involving fewer steps and a 61% yield of cyclopentadecanolide was obtained. The reactive properties of macrolactonization of to-hydroxycarboxylic acids were also studied. The result obtained shows that the priority order of macrolactonization as follows： 11-undecalactone 〉 cyclotridecanolide 〉 cyclopentadecanolide, i. e. the short chain to-hydroxycarboxylic acids were preferentially cyclized.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2007年第5期897-899,共3页
Chemical Journal of Chinese Universities
基金
教育部科学技术重点项目(批准号:204110)
广西自然科学基金(批准号:桂科自0135013
桂科回0448002)资助.
关键词
蒜头果油
环十五内酯
臭氧化
大环内酯
Malania olceifera chum oil
Cyclopentadecanolide
Ozonization
Macrocyclic lactone
