摘要
实验同步记录了豚鼠门静脉的自发活动和物（(86)Rb＋）流出速度。结果表明，K(ATP)开放剂罗卡林（Cromakalim，Cro）（1～10μmol／L）取消豚鼠门静脉的自发活动，增加(86)Rb＋的流出速度。内皮素-1（ET-1）（30nmol／L）增强豚鼠门静脉的自发活动，取消Cro增加(86)Rb+流出速度的作用。实验结果提示，ET-1对K(ATP)有一定的阻滞作用。
The effects of endothelin-1 and cromakalim on 86Rb+ efflux and spontaneous Myogenic activity were studied simultaneously in guinea-pig protal vein. 86Rb+ was used as a tracer ion for K+. The spontaneous activity was increased by endothelin-1 (30 nmol/L). Cromdkalim abolished myogenic activity.86Rb+ efflux was increased by cromakalim (1-10 μmol/L) in a concentration-dependent manner. No Change of 86Rb+ efflux was observed when endothelin-1 was used alone. But the increase of 86Rb+ efflux induced by cromakalim was decreased when endothelin-1 (30 nmol/L) was present simultaneously. The results suggest that endothelin-1 blocks ATP-sensitive K+ channels.
出处
《同济医科大学学报》
CSCD
1997年第1期20-22,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金!39070933
国家卫生部青年基金!90071
关键词
内皮素-1
ATP
钾通道开放剂
门静脉
铷
罗卡林
endothelin-1
ATP-sensitive potassium channel
potassium channel openers
guinea-pig potal vein
