摘要
目的提高对男性狼疮肾炎(LN)临床与病理特征的认识。方法对28例男性LN与同期28例随机选择的女性LN从临床表现、病理学、免疫学特征、治疗及预后进行回顾性分析。结果男性LN较易误诊(P<0.01)和延迟诊断(P<0.05),肾衰竭发生率和需要冲击治疗者多于女性LN(P<0.05),蝶形红斑、关节痛、口腔溃疡较女性少见(P<0.05),ANA阳性率明显低于女性(P<0.05)。病理类型男性Ⅳ型较女性多见,而Ⅱ型较女性少见。在随访1年且资料完整的患者中,女性LN完全缓解或部分缓解的比例明显多于男性LN(P<0.05)。结论男性LN与女性LN的表现有区别,且病情较重,预后差。
Objective：To better understand the characteristics of Male patients with Lupus Nephritis（LN）, Methods：A retrospective analysis of the clinical, pathological and immunological characteristics as well as therapy and prognosis of 28 male lupus nephritis was conducted comparing with 28 synchronic female LN patients, Results： Male patients were susceptible to misdiagnosis （P〈0.01）and delay of diagnosis（P〈0. 05）. The incidence of renal failure and the pulse therapy were higher in the male than those in female patients with SLE, Butterfly erythema, arthragia, dental ulcer and the positive rate of ANA were less common in MLN than in FLN（P〈0.05）. The incidence of types IVLN was more common in male than that in female and the incidence of types Ⅱ LN was les common in male than that in female（P〈0.05）. In the patients with orbicular data during one year follow- up, the rate of complete remission and partial remission was obviously less common in MLN than that in FLN（P〈0,05）. The rates of relapse and mortality were higher in MLN than those in FLN. Conclusion：The clinical features of MLN are different from that of FLN, MLN are susceptible to have much severe conditions and worse prognosis.
出处
《中国中西医结合肾病杂志》
2007年第5期270-272,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
关键词
狼疮性肾炎
男性
肾组织病理
Lupus nephritis Male Renal tissue pathology
