摘要
皮肤Rosai—Doffman病是一种少见病，其病因及发病机制未明。皮损表现多样，病理学特征是真皮内有大量的组织细胞增生并吞噬淋巴细胞。免疫组化为S-100蛋白、CD68（KP-1）阳性，CD1α（OKT6）阴性。本病属自限性疾病，不需特殊治疗。对该病的病因及发病机制、临床表现、组织病理学特点、诊断及鉴别诊断、治疗及预后进行概括。
Cutaneous Rosai-Dorfman disease is a rare disease, and little is known about its etiology and pathogenesis. Its skin lesions vary, and it is histopathologically characterized by proliferation of histiocytes and emperipolesis of engulfed lymphocytes in dermis. These histiocytes are stained positive for S-100 protein and CD68 （ KP-1 ）, but negative for CDla （ OKT6 ）. It is a self-limited disease and does not need specific treatment. This article reviews the etiology, pathogenesis, clinical manifestations, histopathology characteristics, diagnosis, differential diagnosis, treatment and prognosis of the disease.
出处
《国际皮肤性病学杂志》
2007年第3期163-165,共3页
International Journal of Dermatology and Venereology
