摘要
目的:探讨不同乙醛脱氢酶2(ALDH2)基因型对无水乙醇注射(PEI)术后肝功能的影响。方法:测定20例无水酒精注射的肝占位患者术前和术后的肝功能,谷丙转氨酶(ALT)、谷草转氨酶(AST)和谷氨酰转肽酶(GGT),并采用RFLP-PCR方法检测其ALDH2基因型,分析ALDH2遗传型与PEI术后肝功能变化的关系。结果:PEI术后肝功能指标均升高,携带ALDH2*1基因型者术后肝功能ALT和AST的变化分别为25.64±13.24和28.36±19.21,与携带ALDH2*2基因型者的肝功能变化(ALT和AST分别为63.33±27.81和76.11±31.39)相比,其差异统计学有显著性(P值分别为0.022和0.017)。结论:该研究提示携带ALDH2*1基因型者PEI术后可明显增加肝损伤。
Objective： To explore the effect of ALDH2 genotypes on liver function after percutaneous absolute alcohol injection（PAAI）. Methods： Serum ALT, aspartate aminotransferase （AST） and γ- glutamyhransferase （CCT） were examined before and after percutaneous absolute alcohol injection （PAAI）, and aldehyde dehydrogenase-2 genome was detected using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） method. Results： All parameter of the liver function, after the PAAI, were increased and the results of ALT and AST in the ALDH2＊1 genotype patients after PAAI were 25.64±13.24 and 28.36 ±19.21, respectively. In comparison with those in the ALDH2＊2 genotype patients （63.33±27.81 and 76.11±31.39）, there was a significant difference between the two （P=0.022 and P=0.017）. Conclusion： The findings indicated that liver damage might increase largely in the ALDH2＊1 genotypes patients after PAAI.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2007年第10期541-543,共3页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金资助(编号:30460143)
关键词
乙醛脱氢酶2
经皮无水乙醇注射
肝功能
Aldehyde dehydrogenase-2（ALDH2） Percutaneous absolute alcohol injection Liver function
