摘要
以磺胺甲噁唑为模板分子,采用原位聚合法制备了具有特定识别性能的棒状分子烙印聚合物。作为高效液相色谱的固定相实现了磺胺甲噁唑与其结构类似物的分离。磺胺甲噁唑烙印聚合物和目标分子之间的相互作用除了特异性的氢键作用外,也存在着疏水作用。同时考察含水量、流速对分离的影响,论证了分子烙印聚合物选择性专一的作用原理。结果表明,这种棒状聚合物对模板分子及其类似物有很好的分离能力。
Sulfamethoxazole was used as a template for the in - situ preparation of molecular imprinted polymer（MIP） rods as stationary phases in HPLC for the separation and recognition of sulfamethoxazole and its analogues. It was found that the interactions between the MIP and target molecules were not only due to the hydrogen-bonding action but also due to hydrophobic interaction in the imprinted area. The effects of water content and flow rate on the separation were studied. Experimental results showed that the sulfamethoxazole imprinted polymer rod has specific selectivity and high affinity to sulfamethoxazole and its analogues.
出处
《分析测试学报》
CAS
CSCD
北大核心
2007年第3期409-412,共4页
Journal of Instrumental Analysis
基金
河北理工大学科学研究基金项目(200634)
关键词
原位聚合法
分子烙印
磺胺甲噁唑
固定相
分子烙印聚合物
In - situ polymerization method
Molecular imprinting
Sulfamethoxazole
Stationary phase
Molecularly imprinted polymer
