摘要
人血浆中硝苯地平的气相色谱法测定及药代动力学研究吴静张正行王玉（中国药科大学药物分析研究室，南京２１０００９）硝苯地平的血药浓度较低，为了合理地指导临床用药，进行药代动力学研究，必需建立灵敏的体内分析方法。硝苯地平的体内测定方法有同位素标记法［...
A gas chromatographic method for the determination of nifedipine in human plasma is presented. Nifedipine was extracted into toluene and diazepam was used as the internal standard. Chromatography was performed on an OV 101 fused silica column by splitless injection with an electron capture detector. The minimal detectable concentration in plasma was 1 ng·ml -1 . The standard curve was linear in the range 2～150 ng·ml -1 (γ=0 9988). The method has been applied to pharmacokinetic study.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第2期147-150,共4页
Acta Pharmaceutica Sinica
