摘要
探讨非霍奇金淋巴瘤（NHL）患者细胞免疫功能变化及其与病情关系。方法：直接免疫荧光标记流式细胞术（FCM）分析NHL患者和正常人外周血T淋巴细胞亚群，CD19B淋巴细胞，NK细胞及mIL-2R变化。结果：1．初治和复发患者除CDS增高外，CD3，CD4，CD4／CD8比值均明显低于正常对照组，缓解期患者上述免疫指标恢复正常。2．所有患者CD19B细胞均显著减少（P＜0．01）。3．除了初治患者NK细胞低于正常对照组外，其余各组与正常对照组比较无明显差异。4．初治和复发患者淋巴细胞mIL-2R减低，缓解期患者正常。结论：NHL患者细胞免疫功能明显受到抑制，且与病情有关。
Objective: To investigate cell immune function of patients with non - Hodgkin's lymphoma (NHL ).Method: Peripheral blood T cell subsets, NK, CD19 B cell and mIL-2R in 21 patients with NHL and 35 normal con-trols were detected quantitatively with FCM- Result: 1) The number of CD3, CD4 T cell and mlL - 2R markedly re-duced, while those of CD8 T cells increased with a reduction of CD4/CD8 ratio in untreated or relapse patients. Therewere no significant change in T cell subsets and mIL-2R in patients with clinical remission. 2) The number of CD19 Bcell in all patients were much lower than those in normal controls. 3) There were no significant change in NK cells inpatients with clinical remission or relapse except a reduction in untreated patients- Conclusion: NHL patient's cell im-mune function, including T cell subsets, NK, CD19 B cell and mIL- 2R, were depressed. The changes were related tothe tumor stages.
出处
《上海医学》
CAS
CSCD
北大核心
1997年第2期73-75,共3页
Shanghai Medical Journal
