摘要
目的观察柯兴综合征患者垂体—甲状腺轴激素的变化。方法测定６９例柯兴综合征患者血清ＴＴ３（ＲＩＡ法）、ＴＴ４（ＲＩＡ法）、ＴＳＨ（ＩＲＭＡ法）及ＴＳＨ对ＴＲＨ刺激的反应。结果柯兴综合征患者血清ＴＴ３、ＴＴ４、ＴＳＨ及ＴＳＨ对ＴＲＨ刺激的反应均明显低于正常（Ｐ＜０．０１），ＴＴ３下降的百分率高于ＴＴ４。结论柯兴综合征患者垂体—甲状腺轴激素改变主要是由于高皮质醇血症对外周组织５’—脱碘酶的抑制及垂体ＴＳＨ分泌受抑制的结果。
Objective To observe the changes in pituitary thyroid hormones in Cushing′s syndrome.Method The concentrations of serum TT 3,TT 4,TSH and the responses of TSH to TRH were measured in 69 cases. Results The concentrations of serum TT 3,TT 4,TSH and the responses of TSH to TRH in patients with Cushing′s syndrome were significantly lower than those in the normal controls ( P <0.01).A decreased level of TT 3 was found in 45% of the patients,and that of TT 4 in 19%. Conclusion These changes might be caused by the inhibitory effects of hypercorticordism on the activity of 5′-deiodinase and the secretion of pituitary TSH.
出处
《铁道医学》
1997年第1期16-17,共2页
Railway Medical Journal
