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输血相关急性肺损伤的研究进展 被引量:4

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摘要 输血相关性急性肺损伤(TRALI)是指输入血液或血液制品后的数小时内,出现的以急性低氧血症和非心源性肺水肿为主要表现的临床综合征。1985年,Popovsky和Moore首先报道了患者在输入血液后数小时出现的临床呼吸窘迫现象。TRALI见于任何性别与年龄,病死率6%~10%。在美国,如果以每年用血2500万单位计算,每年有5000人发生TRALI,如果按病死率为6%计算,每年死于TRALI的人数有300人。近来,国际上对TRALI的定义进行了界定与完善,并对其防治策略进行了探讨。某些国家还公布了TBALI的预防方法。2004年4月,美国食品与药物管理局(FDA)将TRALI明确列为目前美国输血导致死亡和出现严重临床并发症的首要原因。TRALI发病急,病情重,病死率较高,应引起临床工作者的关注。
出处 《中华内科杂志》 CAS CSCD 北大核心 2007年第5期423-425,共3页 Chinese Journal of Internal Medicine
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