摘要
血管紧张素Ⅱ2型受体(angiotensin Ⅱ type 2 receptor,AT2受体)是近年的研究热点,其主要发挥拮抗血管紧张素Ⅱ1型受体(AT1受体)的作用,如调控血压、抑制心肌肥厚及纤维化、抑制血管重建、保护心功能等心血管效应。但尚存在一些研究不支持以上结论,这可能与AT2受体数量及功能在不同个体、组织类型、病理生理状态下存在差别有关。
Recent years have seen a marked increase in research into angiotensin Ⅱ type 2 receptor（ AT2 ）. It has been shown that AT2 receptor probably mediates arterial blood pressure, inhibits cardiac hypertrophy and fibrosis, inhibits vascular restitution, protects cardiac function by antagonizing angiotensin Ⅱ type 1 receptor, although other relevant research has failed to produce these same results. A possible reason is that the role of AT2 receptor varies between distinct individual tissues and according to the pathophysiological status.
出处
《心血管病学进展》
CAS
2007年第3期415-418,共4页
Advances in Cardiovascular Diseases
