摘要
目的观察苯磺酸左旋氨氯地平和得高宁治疗糖尿病合并肾性高血压和尿白蛋白的疗效。方法将我院34例糖尿病合并肾性高血压患者随机分为观察组和对照组各17例,所有患者受试前停用影响肾功能药物及其他降压药物2周。观察组患者在抗糖尿病治疗的基础上给予苯磺酸氨氯地平2．5mg/次,1次/d,如果2周后血压仍未降至正常(140/90mmHg),则苯磺酸氨氯地平增加至5mg/次,1次/d;对照组患者给予得高宁10mg/次,2次/d,如果2周后血压仍未降至正常,得高宁增加至20mg/次,2次/d。疗程均为12周。结果两组患者治疗前、后收缩压、舒张压间差异均有非常显著性意义(P＜0．01)。观察组患者治疗前、治疗后24h尿蛋白排泄及24h尿蛋白定量间差异均有显著性意义(P＜0．05),观察组患者治疗前、后尿素氮和血肌酐及对照组患者治疗前、治疗后24h尿白蛋白和24h尿蛋白定量、尿素氮、血肌酐间差异均无显著性意义(P＞0．05)。结论苯磺酸左旋氨氯地平不仅能有效控制糖尿病合并肾性高血压,而且还能减少24h尿白蛋白的排泄。
Objective To study the effect of levamlodipineon treated diabetes mellitus complicated with hypertension and urinary albumin concentration. Methods Thirty - four patients with nor - insulin - dependent diabetes patients were divided into two groups at random levamlodipine group （n = 17） and nifedipne group （n = 17）. A twelve weeks double blind treatment phase with the two study drugs. Levamlodipine was started at a dose of 2. 5mg once daily in the morning. Results There were significant diffrence of SBP, DBP between two groups before and after treatment （ P 〈0.01 ）. But the urinary albumin excretion rate was decreased in levanlodipime group （ P 〈 0.05）. Conclusion This study showed that in hypertensive microlbuminuria type Ⅱ diabetic aged patients, levamlodipine not only decreased in blood pressre, but also greatly reduced in urinary albumin excretion than other agent.
出处
《实用心脑肺血管病杂志》
2007年第2期112-113,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
