摘要
哮喘是由多种细胞及其细胞因子参与的气道慢性、复杂的炎症性疾病,以气道炎症,黏液分泌增加,气道高反应性为特点,并且导致反复发作性的喘息、胸闷、咳嗽和气促等症状的发生。自从1980年以来全球哮喘的发病率普遍上升,特别是在儿童中更是明显上升。它已逐渐成为绝大多数工业化国家的主要疾病,影响着成千上万患者的生活质量。目前哮喘的药物治疗中普遍包括肾上腺糖皮质激素,这类药物非特异性地抑制了免疫系统,不仅大大地增加了感染的几率,长期使用这类药物还可能会导致骨质疏松、高血压等疾病,所以最近有很多研究从哮喘发病的分子机制着手,利用各种细胞因子抗体为哮喘的治疗提供了许多更有效、更特异的治疗手段。
Asthma is a chronic complex inflammatory disease of the lungs that results in recurrent wheezing episodes, chest tightness, coughing, and shortness of breath. The responses include the activation of allergen-specific cells and the production of allergen-specific cytokines. Bronchial asthma affects the quality of life of millions and is becoming a major health concern in most of the industrialized countries. Current pharmaceutical treatments for asthma generally include the corticosteroids,which nonspecifically inhibit the immune system. Long-term use of these drugs has been associated with side effects including osteoporosis, high blood pressure, and increased susceptibility to infection. Recently lots of researches have taken advantages of anticytokine as a new therapeutic strategy for bronchial asthma. All those results will hopefully improve the understanding of the pathogenesis of asthma and lead to novel therapeutic approaches to the management of this disease.
出处
《国际呼吸杂志》
2007年第9期689-691,共3页
International Journal of Respiration
