摘要
电压门控钠离子通道由一个大的α-亚单位(260 kDa)和多个β-亚单位(33-36 kDa)所组成。本文重点介绍钠离子通道的结构及其与神经病理性疼痛的关系。
The voltage-gated sodium ion channels are composed of a superfamily of glycoprotein molecules to be able to form membrane channels, which＂ gate＂ in response to changes in membrane potential. The major structure component of the channel is a protein of approximates 260 kDa named α-subunit. Several different sodium channels, α-subunits have been identified and β （β1-4） subunits have been cloned. Their effects upon channel gating functions and action on neuropathic pain were introduced.
出处
《实用疼痛学杂志》
2007年第2期125-128,共4页
Pain Clinic Journal
关键词
离子通道
钠
膜电位
神经病理性疼痛
Ion Channels,Sodium
Membrane Potentials
Neuropathic Pain
