1Itoh S,Itoh F,Goumans MJ,et al.Signaling of TGFβfamily members through Smad proteins[J].Eur J Biochem,2000,267(24):6954-6967.
2Pasche B.Role of TFGβin cancer[J].J Cell Physiol,2001,186(2):153-168.
3Dimberg J,Hugander A,Sirsjo A,et al.A decreased levels of precursor transforming growth factor beta1 in human colorectal cancer[J].Int J Mol Med,2001,7(6):597-601.
4Narai S,Watanabe M,Hasegawa Hi,et al.Significance of transforming growth factor beta1 as a new tumor marker for colorectal cancer[J].Int J Cancer,2002,97(4):508-511.
5Pasche B,Kolachana P,Nafa Km,et al.TbetaR-I(6A) is a candidate tumor susceptibility allele[J].Cancer Res,1999,59(22):5678-5682.
6Pasche B,Knobloch TJ,Bian Y,et al.Somatic acquisition and signaling of TGFBR1*6A in cancer[J].JAMA.,2005,294(13):1634-1646.
7Capozzi E,Della Puppa L,Fornasarig M,et al.Evaluation of the replication error phenotype in relation to molecular and clinicopathological features in hereditary and early onset colorectal cancer[J].Eur J Cancer,1999,35(2):289-295.
8Lu SL,Kawabata M,Imamura T,et al.Two divergent signaling pathways for TGF-beta separated by a mutation of its type Ⅱ receptor gene[J].Biochem Biophys Res Commun,1999,259(2):385-390.
9Grady WM,Willis JE,Trobridge P,et al.Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations[J].Int J Cancer,2006,118(3):600-608.
10Woodford Richens KL,Rowan AJ,Gorman P,et al.SMAD4 mutations in colorectal cancer probably occur before chromosomal instability,but after divergence of the microsatellite instability pathway[J].Proc Natl Acad Sci USA,2001,98(17):9719-9723.
4Shion S R,Singh A B,Moorthy K,et al. Smad4 regulates claudirr I exression in a tyansforming growth factor beta independent manner in colon cancer cells[J]. Cancer Res,2007,67(4) :1571-- 1579.
5Shion S R,singh A B,Moorthy K,et al.Smad4 regulates elaudirr 1 expression in a transforming growth factor beta independent manner in colon cancer cells[J].Cancer Res,2007,67(4):1571.
6Jung B,Smith E J,Doetolero R T,et al.Influence of target gene mutations on survival,stage and histology in sporadic microsatellite unstable colon cancers[J].Int J Cancer,2006,118(10):2509.
7Munoz N M,u PTON m,Rojas A,et al,Transforming grouth factor beta type 11 inactivation induces the malignant transformation of intestinal neplasms in iniated bu A pc mutation[J].Cancer Res,2006,66(20):9837.
