摘要
目的:了解2004年1月—2005年12月天津地区临床分离非发酵革兰阴性杆菌的耐药状况。方法:使用纸片扩散法对天津地区5所三级甲等医院从临床分离的4064株非发酵革兰阴性杆菌进行抗菌药物敏感试验,数据分析采用WHONET 5.3软件。结果:2年间天津地区临床分离非发酵革兰阴性杆菌的分离率已占革兰阴性杆菌的38.4%,并有增高趋势。从构成比来看,以铜绿假单胞菌、不动杆菌和嗜麦芽窄食单胞菌为主,2005年铜绿假单胞菌对亚胺培南敏感率70.7%,亚胺培南对鲍曼不动杆菌保持较高的抗菌活性(96.6%),其他非发酵菌对亚胺培南耐药率达50%以上。2个酶抑制复合制剂头孢哌酮/舒巴坦、哌拉西林/他唑巴坦(除外嗜麦芽窄食单胞菌)对非发酵菌的耐药率均在30%以下。左氧氟沙星对非发酵菌保持较高的抗菌活性。结论:非发酵菌感染呈上升趋势。地区性细菌耐药性分析有利于早期经验治疗时抗菌药物的选择。
Objective： To investigate the antimicrobial resistances among non-fermenter gram-negative bacilli from 5 hospitals in Tianjin area between 2004 and 2005. Methods： Antimicrobial susceptibility testing of non-fermenter was performed using K-B methods. Data were analyzed using WHONET 5.3 software. Results： The isolation showed that approximately the 38.4% were of non-fermenters gram-negative bacilli in two years in Tianjin. The most of pathogens were pseudomonas aeruginosa, acinetobacter, stenotrophomo-nas maltophilia. In 2005, susceptible rate of pseudomonas aemginosa to imipenem was 70.7%. Imipenem in the area remained very highly active against acinetobaetam baumanaii （96.6%）. Other non-fermenters have resistant rates to imipenem as high as 50%, cefoperazon/sulbactam and piperacillin / tazobactam low of 30%. Levofloxacin in the area remained very high activity against non-fermenters. Conclusion： The level of non-fermenter gram-negative bacilli infection presents the up-trend. The local investigate to antimicrebial resistance is advantageous in experimental treatment choice of the antimicrebial to the earlier period.
出处
《天津医药》
CAS
北大核心
2007年第4期256-258,共3页
Tianjin Medical Journal
关键词
革兰氏阴性菌
交叉感染
微生物敏感性试验
天津
gram-negative bacteria cress infection microbial sensitivity tests TIANJIN
