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C反应蛋白与原发性高血压及其危险因素的关系 被引量:2

Relationship between C-Reactive Protein and Risk Factors in Patients with Essential Hypertension
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摘要 目的:探讨C反应蛋白与原发性高血压及其危险因素的关系。方法:测定50例原发性高血压患者(EH组)血清C反应蛋白(CRP)、尿酸(UA)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、胰岛素(Ins)、肾素(PRA)、血管紧张素Ⅱ(ATⅡ)和醛固酮(ALD)水平等生化指标及超声心动图,并与50例健康者(对照组)比较。结果:EH组血清C反应蛋白浓度高于对照组(P<0.05)。经多元逐步回归分析后,C反应蛋白、尿酸、三酰甘油、胰岛素、体质量指数是影响原发性高血压的重要因素(P<0.01)。结论:C反应蛋白、尿酸、三酰甘油、胰岛素浓度及体质量指数与原发性高血压相关,炎症反应参与了原发性高血压的发生、发展。 Objective: To study the relationship of C-reactive protein (CRP) and risk factors in patients with essential hypertension. Methods: The levels of C-reactive protein(CRP), uric acid(UA), triglyceride(TG), total cholesterol(TC), high- density lipoprotein-cholesterol (HDL-C),low-density lipoprotein-cholesterol (LDL-C), fasting blood glucose(FBG), Insulin (Ins),renin aclioity(PRA), angiotension Ⅱ (ATⅡ), aldosterone(ALD) and echocardiography were investigated in 50 essential hypertension patients and 50 controls. Results: The level of serum CRP was significantly higher in essential hypertension group than that of control (P 〈 0.05). Proportional hazard analysis showed CRP, UA, TG, Ins, BMI were the influence factors of essential hypertension (P 〈 0.01 ). Conclusion: The levels of CRP, UA, TG, Ins, BMI were correlated to essential hypertension and inflammation participated in the process of essential hypertension.
出处 《天津医药》 CAS 北大核心 2007年第4期253-255,共3页 Tianjin Medical Journal
关键词 高血压 C反应蛋白质 尿酸 胆固醇 血糖 胰岛素 肾素 血管紧张素Ⅱ hypertension C-reactive protein uric acid cholesterol blood glucose ;insulin; renin ;angiotensin Ⅱ
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  • 1Savoia C, Schiffrin EL. Inflammation in hypertension [J]. Curr Opin Nephrol Hypertens, 2006,15(2) : 152-158.
  • 2Bellelli G, Rozzini R, Battista Frisoni G, et al. Is C-reactive protei nan independent risk factor for essential hypertension [J]? J Hypertens,2001,19(11):2107.
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  • 4杨万松,黄体钢,倪燕萍,刘洪梅.高血压患者肾素-血管紧张素活性与胰岛素水平的关系[J].中华医学杂志,2001,81(15):945-946. 被引量:1
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