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一种扩展的功能磁共振BOLD动力学模型研究 被引量:2

An extended fMRI BOLD Dynamic Model
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摘要 结合Friston的BOLD动力学模型与Agnes Aubert建立的脑电生理和代谢藕合模型,提出了一种扩展的BOLD动力学模型。对改进的模型讨论了血液动力学模型血流的非线性特性,把脑的新陈代谢与血动力学模型的血流、血体积关联起来,并对BOLD模型中的输入信号进行研究。得到了能更好地模拟实际生理过程的仿真结果。 Based on Friston's Blood Oxygenation Level Dependent (BOLD) dynamic model, an extended BOLD dynamic model is proposed in combination with Agnes Aubert's coupling model of brain electrical activity and metabolism. In this model, the cerebral metabolism is connected with blood flow or blood volume of the hemo-dynamic model after discussion of nonlinear character of the blood flow in hemo-dynamic model. The better simulation effect of physiological process is achieved with the restructured input signal of the BOLD model.
出处 《电子科技大学学报》 EI CAS CSCD 北大核心 2007年第2期291-293,共3页 Journal of University of Electronic Science and Technology of China
基金 国家自然科学基金资助项目(30570507) 国家973子项目(2003CB716106) 新世纪优秀人才支持计划 霍英东青年基金资助项目(91041)
关键词 血氧水平依赖 血氧水平依赖动力学模型 仿真 blood oxygenation level dependent blood oxygenation level dependent dynamic model emulation
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参考文献4

  • 1OGAWA S,Menon R S,Tank D W,et al.Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging:A comparison of signal characteristic with biophysical model[J].J.Biophys,1993,64:803-812.
  • 2FRISTON K J,MECHELLI A,TURNER R.Nonlinear responses in fMRI:the balloon model,volterra kernels,and other hemodynamics[J].NeuroImage,2000,12:466-477.
  • 3AUBERT A,COSTALAT R.A Model of the coupling between brain electrical activity,metabolism and Hemodynamic:Application to the Interpretation of Functional Neuroimaging[J].NeuroImage,2002,17:162-1181.
  • 4BUXTON R B,WONG E C,FRANK L R.Dynamics of blood flow and oxygenation changes during brain activation:the balloon model[J].Mag.Reson.Med.,1998,39:855-864.

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