摘要
为进一步了解肺炎对心血管功能影响的性质和机制,采用气管内接种的方法,建立幼鼠金黄色葡萄球菌肺炎模型,观察心肌组织的病理变化;在离体灌流装置上进行左、右心室同时灌流,对冠状动脉流出液中的乳酸脱氢酶(LDH)、肌酸激酶(CK)和不同前负荷下的左有心室功能分别进行测定;并用提取的肺炎组和对照组动物血清灌流正常心脏。结果:(1)肺炎组LDH和CK活性均大于对照组;(2)肺炎组右心室各功能指标显著低于对照组;(3)肺炎组左心室若干功能指标显著低于对照组;(4)肺炎组右心室功能无论在前负荷较低还是较高时均低于对照组,而左心室功能只在前负荷较高时才低于对照组;(5)用肺炎组动物血清和对照组动物血清灌流正常心脏,左、右心功能无明显改变。结果提示:(1)肺炎可造成心肌的损伤。(2)肺炎可降低离体灌流心脏的功能。
The present study was undertaken to elucidate the impacts of pneumonia on cardiovascular function and of its mechanisms. Histologic abnormalities of myocardium in pneumonia were observed in rats with staphylococcus pneumonia and left and right ventricular function as well as levels of lactic dehydrogenase (LDH) and creatine kinase (CK) in coronary perfusates of the heart were detected. The results showed that serum LDH and CK activites were increased and the right ventricular function in pneumonia group was decreased significantly at the same preload as compared with that of control group. The left ventricular function of the pneumonic rats was reduced significantly at elevated preload compared with the control group. Myocardial dysfunction was not found after perfusion with sera obtained from either pneumonic or control rats. These results suggest that staphylococcus pneumonia can result in myocardium damage and impair the cardiac function in vitro.
出处
《中华儿科杂志》
CAS
CSCD
北大核心
1997年第1期29-32,共4页
Chinese Journal of Pediatrics
关键词
肺炎
心室功能
婴幼儿
Pneumonia Ventricular function, left Ventricular function, right
