摘要
目的评价糖类抗原(CA125)和泌乳素(PRL)在观察子宫腺肌病介入治疗疗效中的价值。方法26例子宫腺肌病患者接受经导管子宫动脉栓塞术(TUAE)治疗,其中弥漫型16例,局灶型10例。均采用经导管双侧子宫动脉注射聚乙烯醇颗粒栓塞。在介入治疗前和治疗后3、6、12个月分别测定血中CA125与PRL的含量。结果平均随访18个月,临床缓解率100%。介入治疗前血清CA125和PLR为110.3±86.4kU/L和22.1±8.7ng/mL;治疗后3、6、12个月为38.6±19.9kU/L和17.4±6.8ng/mL;35.8±16.7kU/L和18.1±7.2ng/mL;26.3±17.4kU/L和18.9±6.1ng/mL,较治疗前均明显降低(P<0.01)。结论TUAE术后CA125下降幅度大,是评价子宫腺肌病介入治疗效果的重要指标;PRL下降值较小,且均值仍高于正常,评价疗效的价值有限。
Objective To discuss the clinical value of serum CA125 and PRL in the treatment of adenomyosis by interventional therapy.Methods 26 patients with adenomyosis were underwent with TUAE.Of 26 patients, 16 belonged to diffuse type, while 10 belonged to focal adenomyosis type.Bilateral uterine aterial embolization with polyvinyl alcohol particles was carded out in all patients.Serum CA 125 and PRL were measured after and before the operation.Results The mean duration of follow up was 18 months.Improvement of symptoms was obtained in 100.0% patients.After the operation serum CA125 and PRL decreased from 110.3 ± 86.4kU/L and 22.1 ± 8.7ng/ mL to 38.6 ± 19.9kU/L and 17.4 ± 6.8ng/mL（3 month）;35.8 ± 16.7KU/L and 18.1 ± 7.2ng/mL（6 month）;26.3 ± 17.4kU/L and 18.9 ± 6. 1ng/mL（12 month） （P〈0.0 1）.Conclusion Serum CA 125 and PRL were the important index in appraising effect of TUAE in the treatment of adenomyosis.
出处
《中国血液流变学杂志》
CAS
2007年第1期142-143,162,共3页
Chinese Journal of Hemorheology
