摘要
目的 研究IL-18水平与冠状动脉病变程度的关系及其临床意义。方法 选择2005年2～12月在湖北襄樊市中心医院心内科住院的患者共91例，其中急性冠脉综合征（ACS）患者60例、稳定型心绞痛（SAP）患者31例和对照组55例。所有入选患者均进行选择性冠状动脉造影检查，冠心病组根据冠脉造影结果分为A组（50％≤冠脉狭窄〈70％）、B组（70％≤冠脉狭窄〈90％）及C组（90％≤冠脉狭窄）。采用ELISA方法检测动脉血IL-18水平。结果 冠心病患者（ACS组和SAP组）与对照组相比IL-18明显增高（P〈0．01）；IL-18在C组中明显升高（P〈0．01）。结论 IL-18水平与冠脉病变及其严重程度明显相关，可以作为评估冠心病严重程度及预后的重要指标之一。
Objective To investigate the relationship between IL-18 level and severity of coronary artery lesion, Methods 91 patients [60 cases of acute coronary syndrome （ACS） and 31 cases of stable angina pectoris （SAP）] and 55 healthy control patients were enrolled. All patients were performed coronary angiography, and divided into three groups as follows, A group （50%≤stenoses 70%）, Bgroup（70%≤stenoses〈90%） and C group（90%≤stenoses）. IL-18 in artery blood was measured by ELISA assay. Results As compared with that of controls, the patients with ACS or SAP had significantly higher IL-18 concentration （P〈0. 01）. The level of IL-18 was much higher in C group （P〈0.01）. Conclusion IL-18 is associated with severity of coronary artery lesion, and helps evaluating coronary heart disease severity and its outcome.
出处
《国际检验医学杂志》
CAS
2007年第4期321-322,共2页
International Journal of Laboratory Medicine
关键词
白细胞介素18
冠状动脉疾病
心胶痛
Interleukin-18
Coronary diseases
Angina pectoris
Syndrome
