摘要
对甲基肉桂酸乙酯经N-溴代丁二酰亚胺溴化制得对溴甲基肉桂酸乙酯,在离子液体N-正丁基吡啶四氟硼酸盐中,与咪唑室温缩合后碱性水解,得抗血栓药奥扎格雷钠,总收率为67%。
Sodium ozagrel, an anti-thrombosis agent, was synthesized from ethyl 4-methyl cinnamate by bromination with NBS to give ethyl 4-bromomethyl cinnamate, which was condensed with imidazole in ionic liquid N-n- butylpyridinium tetrafluoroborate followed by hydrolysis with an overall yield of about 67 %.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2007年第5期325-326,共2页
Chinese Journal of Pharmaceuticals
关键词
奥扎格雷
抗血栓药
合成
ozagrel
anti-thrombosis agent
synthesis
