摘要
目的筛选乙肝舒康胶囊干浸膏的最佳制备工艺。方法采用正交试验法,优选醇提工艺和水提工艺。结果乙肝舒康胶囊干浸膏的最佳制备工艺为,取处方比例的何首乌,碎成细粉,备用;剩余的何首乌、叶下珠、丹参、虎杖均碎成最粗粉,加入药材12倍量的60%乙醇加热回流提取3次,每次1 h;醇提后的药渣与白花蛇舌草、黄芪的最粗粉加入全部药材(按干品计)8倍量的水,煎煮2次,每次1.5 h。结论优选出的制备工艺可行,用该工艺制备的胶囊质量稳定可靠。
Objective To optimize the best preparation technique of Yiganshukang capsule dry extractum. Methods The orthogonal design was used to optimize the best extractive technique with alcohol and water. Results The optimal preparation conditions were as follows： grinding Radix Polygoni multiflori into powder with the proportion on recipe for use; grinding the surplus Radix Polygoni multiflori, Yexiazhu, Radix Salviae miltiorrhizae, Rhizoma Polygoni cuspidati into coarse powder, adding 60% alcohol with 12 times amount of the medical material, heatig and extracting by refluxing for 3 times with 60 min each time; adding water with 8 times amount of the total medical material（in dry） into the medicinal drugs after extracting in alcohol and the powder of Herba Hedyotis diffusae and Radix astragali, decocting by refluxing for twice with 90 min each time. Conclusion The selected techniaue in oreoaration is reliable and stable.
出处
《中国药业》
CAS
2007年第8期42-44,共3页
China Pharmaceuticals
关键词
正交试验法
乙肝舒康胶囊干浸膏
提取工艺
orthogonal design
Yiganshukang capsule dry extractum
extractive technique
