摘要
目的探讨尿微量蛋白α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)、白蛋白(mAlb)、免疫球蛋白G(IgG)和N-乙酰-β-D-氨基葡萄糖苷酶(NAG)对妊娠期糖尿病(GDM)患者肾脏损害的早期诊断价值。方法以30例正常妊娠妇女为正常对照组,60例GDM妇女根据血液HbA1c的水平(HbA1c<6.5%,6.5～8.0%,>8.0%)分为3组。所有受试者留晨尿10ml离心,收集上清液,检测尿四项微量蛋白和NAG。结果GDM1组患者,尿α1-MG、β2-MG与对照组的有显著性差异(P<0.01),其余各项指标无差异(P>0.05);GDM2组患者,尿α1-MG、β2-MG、mAlb与正常对照组和GDM1组的有显著性差异(P<0.01),尿NAG和IgG尿NAG和IgG与上述两组无显著性差异(P>0.05);GDM3组患者,尿NAG和α1-MG、β2-MG、mAlb、IgG与正常对照组和GDM1、2组比较均有显著差异(P<0.01)。结论尿微量蛋白和NAG可作为妊娠期糖尿病肾脏损害的早期诊断指标。
Objective： To study the early diagnosis value of α1 - microglobulin （α1 - MG）, β2 - microglobulin （ β2 - MG）, microalbumin （mAlb） , immunoglobulin （IgG） and N -acetyl - β -D -glucosaminidase （NAG） on renal injures of gestational diabetes mellitus patients. Methods： 30 cases normal pregnant women of healthy control and 60 cases gestational diabetes mellitus patients are divided into three groups according to the level of blood glycatedhaemoglobin （ HbA1c 〈 6. 5%, 6. 5 - 8.0%, 〉 8.0% ）. All those cases took morning urine, collecting 10 milliliter of the surface clear liquid after centrifuge, detecting four uromicroproteins and NAG. Results ： Urine α1 - MG andβ2 - MG in GDM1 group had significant differences with those in the healthy control （ P 〈 0. 01 ）, but other three indicators between the two groups were similar （ P 〉 0. 05）. There were significant differernces of urine α1- MG, β2 - MG and mAlb among GDM2 group , the healthy control and GDM1 group （ P 〈 0. 01 ）, and IgG and NAG were similar （ P 〉 0. 05）. Compare with healthy control, GDM1 and GDM2 groups, these five indicators above had significant differences in GDM3 group. Conclusion ： The four uromicroproteins and NAG in urine can be used as early diagnostic indicators of renal injury of gestational diabetes mellitus patients.
出处
《中国优生与遗传杂志》
2007年第4期29-30,共2页
Chinese Journal of Birth Health & Heredity
