摘要
本文用混合放射性碘给3个组大鼠腹腔注射,放射性活度分别为148、74和37×10~4Bq,观察了致癌效应。 雄性大鼠在74×10~4Bq组甲状腺肿瘤发生率最高,为62.5％,其次是37×10~4Bq组,为54.6％;雌性大鼠在37×10~4Bq组肿瘤发生率最高,为57.1％。主要为甲状腺肿瘤,其次为乳腺肿瘤。 雌、雄性大鼠甲状腺肿瘤均来自滤泡上皮细胞或副滤泡上皮细胞。良性肿瘤中以多形性滤泡腺瘤为主,恶性肿瘤中则以髓样癌为主。混合放射性碘的致癌性高于其中任何单一放射性碘的致癌性,主要表现为甲状腺恶性肿瘤与良性肿瘤发生率之比的比值增高,由0.0或O.6可升高到10.0。
In the present paper, Mixed radioiodines were injected intraperitane-ously into rats with dose of 148×10~4, 74×10~4, 37×l0~4 Bq and null respectively in4 groups to observe their carcinogenic effects. The highest incidence of thyroid tumours in male rats treated with 74×10~4 Bq ofradioiodines was 62.5% and the next was 54.69% in which treated with 37×10~4 Bq.The highest incidence of tumours in female rats treated with 37×10~4 Bq of ra-dioiodines was 57.1%. The majority of tumours was derived from thyroid and thenext from mammary gland. The thyroid tumours in both male and female rats were all originated from fo-llicular epithelial of para-epithelial cells. The main type of benign tumours was polymorphofollicular adenoma and the ma-lignant one medullary carcinoma. The carcinogenests of mixed radioiodines was stronger than that from any singleradioiodine which was a component of them, appearing the ratio of malignant to beni-gn tumours being increased from 0. 0 or 0. 6 in the rats treated with only Ⅰ-125, Ⅰ-131, or Ⅰ-132 up to 10.0.
出处
《辐射研究与辐射工艺学报》
CAS
CSCD
北大核心
1990年第1期33-38,共6页
Journal of Radiation Research and Radiation Processing
关键词
放射性
碘
大鼠
癌
鼠
甲状腺
肿瘤
Mixed radioiodines
Thyroid
Adenomas
Carcinomas
Rats
