摘要
用簧片弹击大鼠枕骨结节部位造成大鼠脑干损伤。模型成功的指标包括：弹击后立即出现昏迷，角膜、痛觉、惊觉等反射消失，并于伤后３ｈ内死亡；大体观察无颅骨骨折，无或仅见少许蛛网膜下腔出血，无肉眼可见的脑挫伤，脑干纵切面可有少许小点状出血；光镜下仅见脑干水肿及少量小灶性出血等轻微病理学变化。造成脑干损伤时大鼠头部受的力为１．６～２牛顿（Ｎｅｗｔｏｎ，Ｎ）。当打击力大于２Ｎ时可造成广泛性脑损伤，打击力小于１．６Ｎ时仅形成脑震荡模型。
Brain stem injury model was sucessfully produced in rats by hitting the occipitial protuberance with a strip of steel. The indexes include: Hitting resulted in immediate coma, loss of corneal reflex, startle reflection and pain reflection; the animals died within 3 hours after hitting; gross obersvation shows no skull fracture, no or a little subarachnoid hemorrhage, no cerebral contusion, only a few small spotty hemorrhages in brain stem in some cases. Light microscopic survey shows only minor pathologies, such as spotty hemorrhage and brain stem edma. The elastic force that produces rats' brain stem injury is 1.6￣2 N. When the force surpasses 2 N, it can be applied for making the model of extensive craniocerebral injury; As the force is less than 1.6 N, it may cause brain concussion.
出处
《中山医科大学学报》
CSCD
1997年第1期62-64,共3页
Academic Journal of Sun Yat-sen University of Medical Sciences
基金
国家自然科学基金
