摘要
目的探讨心律平联合血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体拮抗剂(ARB)对伴有左室肥厚的高血压室性心律失常患者QT离散度(QT interval disperson,QTd)的影响。方法检测60例伴有左室肥厚的高血压室性心律失常患者应用心律平和ACEI或ARB前后的QTd,并与60例健康对照者进行比较。结果病例组用药前与正常对照组相比,QTd有明显延长(P<0.05)。用药1个月后,病例组QTd较用药前略有缩短,但无统计学意义(P>0.05);用药3个月后,QTd较用药前仍有缩短与用药1个月时相似(P>0.05);用药6个月后,QTd较用药前有较明显缩短(P<0.05)。结论心律平联合ACEI或ARB应用于高血压伴左室肥厚及室性心律失常的患者时QTd无延长,是安全的用药方案。
Objective To evaluate the effect of propafenone combined with angiotensin converting enzyme inhibitor （ACEI） or angiotenSin Ⅱ type 1 receptor antagonist（ARB） on QT interval dispersion （QTd） in hypertensive patients with left ventricular hypertrophy and ventricular arrhythmia. Methods QTd was mesured in 60 healthy controls and 60 hypertensive patients before and after 1 month＇, 3 months＇ and 6 months＇ treatment. Results Compared with healthy controls,QTd was obviously increased in hypertensive patients with left ventrictdar hypertrophy and ventrictdar arrhythmia（ P 〈 0.05）. After 6 months＇ treatment of propafenone and ACEI or ARB, QTd was signilicandy decreaed （ P 〈 0.05 ） . Conclusion This Study suggest that the combination of propafenone with ACEI or ARB can be safely used in hypertensive patients with left ventrictdar hypertrophy and ventricular arrhythmia.
出处
《四川医学》
CAS
2007年第4期380-381,共2页
Sichuan Medical Journal
关键词
心律平
高血压
室性心律失常
QT离散度
propafenone
hypertension
ventricular arrhythmia
QT interval dispersion
