摘要
为了探讨儿童白血病的病因，作者进行了1：1配对病例对照研究，结果表明儿童白血病的主要医源性危险因素是：儿童X线暴露（OR=4．53），儿童服用氯霉素（OR=3．60），儿童服用解热镇痛类药物（OR=1．93）。X线暴露与氯霉素、氯霉素与解热镇痛药对儿童白血病的发生有正的交互作用，人群归因危险度分析表明人群中71％的病例可归因于上述危险因素。
A 1: 1 matched case-control study was conducted to investigate the etiology of childhood leukemia. It was found that there were three main iatrogenic risk factors: (1) Children's postnatal X-ray exposure, OR= 4. 53; (2) Children took choramphenicol, OR=3. 60; (3) Children took antipyretic/analgesic drugs, OR= 1. 93. The analysis of the population attributable risk showed that 71% case of childhood leukemia can attributed to these three risk factors. The interaction among the risk factors was estimated, the result showed that there was a positive interaction between the X-ray exposure and choramphenicol on additive model. Based on the multiplicative model, it showed a positive interaction between chorampphenicol and antipyetic/anagesic drugs.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1997年第1期16-18,共3页
Cancer Research on Prevention and Treatment
