摘要
AIM: To study milk consumption and subjective milk- related symptoms in adults genotyped for adult-type hypolactasia. METHODS: A total of 1900 Finnish adults were genotyped for the C/T-13910 variant of adult-type hypolactasia and filled in a structured questionnaire concerning milk consumption and gastrointestinal problems. RESULTS: The C/C-13910 genotype of adult-type hypolactasia was present in 18% of the study population. The prevalence of the C/C-13910 genotype was higher among subjects who were undergoing investigations because of abdominal symptoms (24%, P < 0.05). Those with the C/C-13910 genotype drank less milk than subjects with either the C/T-13910 or the T/T-13910 genotype of lactase persistence (18% vs 38%; 18% vs 36%, P < 0.01). Subjects with the C/C-13910 genotype had experienced more gastrointestinal symptoms (84%) during the preceding three-month period than those with the C/T-13910 (79%, P < 0.05) or the T/T-13910 genotype (78 %, P < 0.05). Only 9% (29/338) of the subjects with the C/C-13910 genotype consumed milk and reported no symptoms from it.CONCLUSION: Gastrointestinal symptoms are more common among adults with the C/C-13910 genotype of adult-type hypolactasia than in those with genotypes of lactase persistence.
AIM： To study milk consumption and subjective milk-related symptoms in adults genotyped for adult-type hypolactasia. METHODS： A total of 1900 Finnish adults were genotyped for the C/T-13910 variant of adult-type hypolactasia and filled in a structured questionnaire concerning milk consumption and gastrointestinal problems. RESULTS： The C/C-13910 genotype of adult-type hypolactasia was present in 18% of the study population. The prevalence of the C/C-13910 genotype was higher among subjects who were undergoing investigations because of abdominal symptoms （24%, P 〈 0.05）. Those with the C/C13910 genotype drank less milk than subjects with either the C/T-13910 or the T/T-13910 genotype of lactase persistence （18% vs 38%; 18% vs 36%, P 〈 0.01）. Subjects with the C/C-13910 genotype had experienced more gastrointestinal symptoms （84%） during the preceding three-month period than those with the C/T-13910 （79%, P 〈 0.05） or the T/T-13910 genotype （78 %, P 〈 0.05）. Only 9% （29/338） of the subjects with the C/C-13910 genotype consumed milk and reported no symptoms from it.CONCLUSION： Gastrointestinal symptoms are more common among adults with the C/C-13910 genotype of adult-type hypolactasia than in those with genotypes of lactase persistence.
基金
the Sigrid Jusélius Foundation, Helsinki, Finland
the Foundation for Nutrition Research, Helsinki, Finland
the Research Foundation of Alfred Kordelin, Helsinki, Finland
Helsinki University Hospital Research Funding, Helsinki, Finland
the Foundation for Promoting Occupational Medicine in Finland,Helsinki,Finland
the Academy of Finland
