摘要
目的探讨超声造影评价慢性病毒性肝炎肝纤维化的应用价值。方法肝纤维化组22例,肝硬化组7例,均经超声引导下肝组织活检病理证实;对照组10例,来自健康的自愿者。采用声诺维(SonoVue)造影剂,对患者实行团注法注入造影剂,实时灰阶超声造影检查。结果肝动脉、门静脉显影时间在三组之间差异无统计学意义。肝纤维化组的肝静脉显影时间(即肝脏通过时间)较对照组延长,差异有统计学意义,时间分别为(25.50±4.25)s、(21.50±5.52)s;肝硬化组的肝脏通过时间较肝纤维化组、对照组缩短,差异无统计学意义,时间分别为(16.57±2.64)s、(25.50±5.52)s、(21.50±4.25)s;肝纤维化组、肝硬化组的肝实质增强峰值时间较对照组延长,差异有统计学意义,时间分别为(40.46±8.92)s、(40.96±12.61)s、(29.82±7.88)s。结论本研究初步显示超声造影技术可以应用于病毒性肝炎肝纤维化的定量诊断,对临床治疗及预后有一定的帮助。
Objective To investigate the application value of contrast - enhanced sonography in the hepatic fibrosis of the patients with chronic viral hepatitis. Methods There were 22 cases in the group of hepatic fibrosis, 7 cases in the group of hepatocirrhosis. All the cases in both the groups were pathologically confirmed by liver tissue biopsy guided by ultrasound. There were 10 cases in the control group of healthy volunteers. A real time gray - scale contrast enhanced US was performed with SonoVue bolus injection. Results There were no significant differences in the arrival time of hepatic artery and penal vein among the three groups. The arrival time （25.50 ± 4.25 ） s of portal vein in the hepatic fibrosis group showed a later onset than that （21.50 ± 5.52） s in the control group and there was a significant difference between the two groups. The arrival time （ 16.57 ± 2.64） s of portal vein in the hepatocirrhosis group was shorter than that both in the hepatic fibrosis group and in the control group, and there was a significant difference among them. The enhanced peak time of hepatic parenchyma both in the groups of hepatic fibrosis and hepatocirrhosis showed a later onset than that in the control group, and there was a significant difference. Their enhanced peak time are （40.46 ± 8.92） s, （40.96 ± 12.61 ） s and （29.82 ± 7.88） s respectively. Conclusion This study indicates preliminarily that contrast - enhanced sonography can be used in the quantitative diagnosis of hepatic fibrosis of the patients with viral hepatitis and it is helpful in the clinical treatment and prognosis.
出处
《临床超声医学杂志》
2007年第4期205-207,共3页
Journal of Clinical Ultrasound in Medicine
关键词
肝炎
病毒性
慢性
超声检查
造影剂
Chronic, viral, hepatitis
Uhrasonography
Contrast agents
