摘要
目的探讨左乙拉西坦(LEV)作为添加治疗对部分性癫癎患者认知功能及生活质量的影响。方法研究分两个阶段进行。第一阶段,采用随机、双盲、安慰剂对照的方法,为期16周;第二阶段为开放性试验,为期24周。在入组时、试验的16周末和24周末分别检测患者认知功能,并进行生活质量量表评价。结果 (1)第16周末,LEV 组威斯康星卡片分类测验(WCST)操作时间与入组时基线的差值分别为-110.3和-122.9,延迟逻辑记忆与基线差值为3.4,与入组时比较差异有统计学意义(P<0.01);与健康相关的生活质量(HRQOL)中认知功能及社会功能均有改善(P<0.01)。(2)第40周末,与入组时比较,LEV 组与安慰剂组连线测验 A 型、B 型时间与基线的差值分别为-13.3、～20.5和-5.2、-15.2,较入组时缩短,WCST 持续错误数减少,操作时间减少,延迟视觉记忆增加(P<0.05),HRQOL 中综合 QOL、总体健康水平、认知功能、社会功能均有改善(P<0.05)。结论 LEV 作为添加治疗在控制癫癎发作的同时可以部分改善癫癎患者认知功能和生活质量。
Objective To explore the effect of levetiracetam （LEV） on cognitive function and quality of life of patients with partial seizure. Methods There were two phase for this study. Phase one was a randomized, double-blind, placebo-controlled study for 16 weeks. Phase two was an open label period for 24 weeks. Medicated patients underwent test on the cognitive function and Health Related Quality of Life （HRQOL） at the baseline respectively at the end of 16 weeks and at the end of 40 weeks. Results （ 1 ） Compared the result at the end of 16 weeks with the baseline, LEV group used less time to do Wisconsin card sorting test （ WCST, reduce scores - 110. 3 ）, delayed logical memory were improved （ reduce scores 3.4, P 〈 0. 01 ） ; Cognitive functioning and Social function in HRQOL were all improved （ P 〈 0. 01 ）. （2） Compared the result at the end of 40 weeks with the baseline, The time of Trail making test （TMT） type A and type B in two groups were shortened, the reduce scores of LEV group were - 13.3 and -20. 5, that of placebo group were - 5. 2 and - 15. 2. In two groups the persistent error number and operation time of WCST were declined as well. Delayed optical memory was improved （ P 〈 0. 05 ）. Overall QOL, Overall health, cognitive functioning, social function in HRQOL were all improved in all patients （ P 〈 0. 05 ）. Conclusion LEV as an adjunctive treatment to partial seizure can effectively control seizure attacks as well as to improve the cognitive functioning and health related quality of life in epilepsy patients.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2007年第3期154-156,共3页
Chinese Journal of Neurology
关键词
癫痫
部分性
抗惊厥药
吡拉西坦
随机对照试验
认知
生活质量
Epilepsies, partial
Anticonvulsants
Piracetam
Randomized controlled trials
Cognition
Quality of life
