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Survivin的生物学特性及其在皮肤病中表达的意义

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摘要 Survivin作为凋亡抑制蛋白IAP家族的成员之一,不仅具有抑制由线粒体诱导的凋亡的作用,还协同单一的p53基因抑制凋亡的发生,同时在血管生成过程中抑制血管内皮细胞的凋亡,保护新生血管。Survivin在正常表皮不表达,但在很多皮肤疾病中有充分表达。本文综述了Survivin的分子结构、抑制凋亡的机制以及在各种皮肤组织中,Survivin的表达与诊断、预后、治疗的意义。
作者 栾莉 孙令
机构地区 大连医科大学附属第二医院皮肤科
出处 《中国麻风皮肤病杂志》 2007年第4期328-331,共4页 China Journal of Leprosy and Skin Diseases
关键词 SURVIVIN 细胞凋亡 皮肤病 生物学特性
分类号 R751 [医药卫生—皮肤病学与性病学]
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参考文献24

  • 1马艳萍,邹萍,肖娟,黄士昂.Survivin基因在脐血CD_(34)^+干/祖细胞中的表达及意义[J].中华血液学杂志,2003,24(5):238-240. 被引量：6
  • 2Verdecia MA,Huang H.Structure of the human anti-apoptotic protein Survivin reveals a dimeric arrangement.Nat Struct Biol 2000;7:602-608.
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  • 5Grossman D,Kim PJ.Transgenic expression of Survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53.J Clinical investigation 2001; 108(7):991-999.
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二级参考文献7

  • 1Moriai R, Asanuma K, Kobayashi D, et al. Quantitative analysis of the anti-apoptotic gene survivin expression in malignant haematopoietic cells.Anticancer Res, 2001,21:595-600.
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  • 4Kamihira S, Yamada Y, Hirakata Y, et al. Aberrant expression of caspase cascade regulatory genes in adult T-cell leukaemia: survivin is an important determinant for prognosis. Br J Haematol,2001,114:63-69.
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  • 6Fukuda S, Pelus LM. Regulation of the inhibitor-of-apoptosis family member survivin in normal cord blood and bone marrow CD34 + cells by hematopoietic growth factor: implication of survivin expression in normal hematopoiesis. Blood, 2001, 98:2091-2100.
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共引文献5

中国麻风皮肤病杂志
2007年 第4期

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