摘要
目的探讨胰腺癌患者外周血促血管生成因子中血管内皮细胞生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)及类胰岛素生长因子(IGF-1)浓度与临床病理学特点之间的关系。方法酶联免疫吸附试验测定32例胰腺癌可切除患者,24例胰腺癌不可切除患者和20例健康人外周血的 VEGF、bFGF 及 IGF-1浓度,分析其与胰腺癌患者性别、年龄、病理分级、肿瘤大小、有无淋巴结及远处转移、是否侵犯血管及临床分期的关系。结果胰腺癌患者 VEGF 及 bFGF 浓度显著高于健康人(P<0.01),IGF-1浓度差异无统计学意义(P>0.05);胰腺癌不可切除组较可切除组 VEGF 显著升高(P<0.05),bFGF 及 IGF 浓度差异无统计学意义(P>0.05);VEGF 与胰腺癌分化、淋巴结转移、血管侵袭、远处转移及临床分期相关;bFGF 与肿瘤大小及肿瘤分化相关;IGF-1与血管侵袭相关。结论胰腺癌进展过程中特有的生物学特性与胰腺癌不同时期的血管形成调控密切相关,促血管生成因子对于胰腺癌的进展发挥至关重要的作用,检测外周血促血管生成因子的表达对于胰腺癌临床筛查、诊断及治疗可能具有重要意义。
Objective To investigate the relationship between VEGF, bFGF and IGF-1 serum concentration and progression of pancreatic carcinoma. Methods Fifty-six patients with pancreatic carcinoma were divided into resectable group（ n = 32） and unresectable group（ n = 24）. Another group was normal group（ n = 20 ）. The expression and significance of these proangiogenic factors were respectively analyzed in different groups. Results For pancreatic carcinoma group, concentrations of VEGF and bFGF were significantly higher than these of normal group （ P 〈 0. 01 ）. Serum VEGF was significantly correlated with the resection of pancreatic carcinoma （ P 〈 0. 05 ） while bFGF and IGF were not. According to univariate analysis, serum VEGF was correlated with tumor grade, nodal disease, vascular invasion, distant metastases and tumor stage. ,Serum bFGF was associated with tumor size and grade. Serum IGF-1 was correlated with vascular invasion. Conclusions Angiogenic factors play important roles in growth, invasion and metastasis. Detection of serum proangiogenic factors may have potential value in diagnosis and prognosis of pancreatic carcinoma.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2007年第7期496-498,共3页
Chinese Journal of Surgery
