摘要
目的研究Myocilin（MYOC）基因Gln368STOP位点突变与原发性开角型青光眼（POAG）的相关性。方法以POAG患者和对照组基因型分布的优势比（OR）为统计量。电子检索和手工检索相关文献，剔除不符合要求的文献，应用RevMan 4．2软件对各纳入研究结果进行异质性检验，采用相应数学模型进行数据合并，并评价发表偏倚的影响。结果共检索到符合要求的文献11篇，均为病例-对照研究，POAG患者共3077例，对照组共2063例，数据合并结果显示POAG组与对照组发生Gln368STOP位点突变的OR值（95％C1）为6．01（2．57～14．04，P〈0．01）。结论MYOC基因Gln368STOP位点突变与POAG患病风险增加相关，是POAG发病的危险因素之一。
Objective To study the association between Myocilin （MYOC） Gln368STOP mutation and primary open angle glaucoma （POAG） by means of Meta-analysis. Methods Odds ratios （OR） of MYOC Gln368STOP genotype distributions in POAG patients verse the controls were analyzed. All the relevant reported studies were identified. Poor-qualified studies were eliminated, and the risk of publication bias was excluded. Meta-analysis software, RevMan 4. 2, was applied for investigating heterogeneity among individual studies and summarizing the effects across studies. Results A total of 3077 POAG cases and 2063 controls from 11 studies were included. No heterogeneity among these studies was noticed（ P = 0. 79）. The pooled OR （with 95% CI） of MYOC Gln368STOP in POAG cases versus that in the controls was 6. 01 （2.57-14.04,P 〈 0.01 ）. Conclusion MYOC Gln368STOP mutation might be associated with the increased risk of POAG and is one of its risk factors.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2007年第4期361-366,共6页
Chinese Journal of Ophthalmology
