摘要
目的探讨上海市儿童角膜移植患者的疾病分类、年龄及性别分布等临床特点。方法通过多中心合作的方式，回顾性分析上海市4所医院于2003年1月至2006年1月期间121例（122只眼）连续住院进行角膜移植手术患儿的临床资料。患儿年龄均在17岁以下。应用SPSS13．0统计软件分析患者的原发病、年龄及性别等数据。结果121例（122只眼）息儿中，外伤性角膜瘢痕27例（22．3％），角膜炎后角膜白斑24例（19．8％），先天性角膜混浊14例（11．6％），圆锥角膜13例（10．7％），角膜溃疡11例（9．1％），移植物排斥6例（5．0％），带状角膜变性6例（5．0％），化学伤6例（5．0％），热灼伤5例（4．1％），皮样瘤5例（4．1％）及先天性遗传性角膜内皮营养不良4例（3．3％）。患儿中，男性77例，女性44例，男女性比例为1．75：1．00。患儿年龄四分位数范围为8～14岁，中位数为11岁。角膜移植患儿手术以穿透性角膜移植术为主，为95例（78．5％）；行板层角膜移植术患者为19例（15．7％）；穿透性角膜移植术联合其他手术为7例（5．8％）。结论外伤性角膜瘢痕和角膜炎后角膜白斑是儿童角膜移植手术的主要原因。角膜移植患儿以学龄期儿童为主，且男性比例较高。
Objective To determinate the clinical characteristics of children underwent corneal transplantation in Shanghai, including the indications, the age and gender distributions, etc.. Methods Records of 122 keratoplasties in 122 eyes of 121 children below 17 years old, undertaken from January 1, 2003 to January 1, 2006, were gathered by four ophthalmic units in Shanghai as a multiple centre study and the data were analyzed by the statistic software SPSS 13.0 retrospectively, especially on the indication, the age and gender distributions. Results One hundred and twenty one patients were enrolled in this study. Traumatic corneal sear （22. 3% ） and scarring after keratitis （ 19. 8% ） were the leading indications for keratoplasty, followed by congenital corneal opacity （ 11.6% ） , keratoconus （ 10. 7% ） , corneal ulceration （9. 1% ）, graft rejection （5.0%） , band keratopathy （5.0%） , chemical injury （5.0%） , thermal burns （4. 1% ）, comeoconjuctival dermatoid （4. 1% ） and congenital hereditary corneal endothelial dysfunction （ 3. 3% ）. The median age was 11.0 years with the interval quartile range at 8-14 years. The number of male patienta （77） was approximately twice as many as the female patients （44）. Ninety-five patients underwent penetrating keratoplasty （78. 5% ） , 19 patients underwent lamellar keratoplasty （ 15.7% ） and 7 patients underwent combined penetrating keratoplasty with other surgeries （5.8%）. Conclusions Traumatic corneal scar and scarring after keratitis were the leading indications. The age of operated cases mainly in the school age. Male is more frequent than the female.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
2007年第4期303-306,共4页
Chinese Journal of Ophthalmology
关键词
角膜移植
儿童
年龄分布
性别分布
Corneal transplantation
Child
Age distribution
Sex distribution
