摘要
目的研究艾司洛尔和尼卡地平对围术期心肌缺血的保护效应。方法60例ASAⅡ-Ⅲ级拟全麻下行择期非心脏手术的心肌缺血患者，随机分成实验组和对照组各30例。实验组在全麻诱导气管插管后给艾司洛尔40μg/（kg·min）和尼卡地平1μg／（kg·min）静注，对照组给予生理盐水。分别于麻醉前、诱导后和手术结束时监测ECGS-T段下移幅度和血清cTnI浓度。结果实验组和对照组于麻醉前和诱导后S-T段下移幅度和血清cTnI值均无显著性差异。手术结束后，实验组S-T段下移幅度和血清cTn｜值较麻醉前无显著性差异，对照组S-T段下移幅度和血清cTnI值较麻醉前显著增大（P〈0．05）；组间S-T段下移幅度和血清cTnI值有显著差异（P〈0．05）。结论艾司洛尔和尼卡地平对围术期心肌缺血具有保护效应。
AIM To investigate the protective effect of Esmolol and Nicardipine on myocardial ischemia during preoperative period. METHODS Sixty patients with myocardial ischemia undergoing selective noncardiac surgery were randomly divided into experimental group, who received Esmolol 40 μg/（kg ·min） and Nicardipine 1 μg/（ kg · min） after endotracheal intubation, and control group, who received normal saline as control. Downward shift distance of ECG S-T section and serum cTnI value were monitored before anesthesia, after induction of anesthesia and at the end of the surgery. RESULTS In two groups, the downward shift distance of ECG S-T section and serum cTnI value were not significantly different between before anesthesia and after induction of anesthesia. At the end of the surgery, in experimental group, the downward shift distance of ECG S-T section and serum cTnI value were not significantly different compared with those before anesthesia . In control group, the downward shift distance of ECG S-T section and serum cTnI value significantly increased compared with those before anesthesia （ P 〈 0.05 ）. The downward shift distance of ECG S-T section and serum cTnI value were significantly different between two groups （P 〈 0.05）. CONCLUSION Esmolol and Nicardipine exert some protective effect on myocardial ischemia during preoperative period.
出处
《心脏杂志》
CAS
2007年第2期212-214,共3页
Chinese Heart Journal
