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缺血期急性高血糖加重大鼠心肌缺血/再灌注损伤 被引量：1

Hyperglycemia during ischemia aggravates reperfusion-mediated myocardial injury in rats
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摘要 目的探讨急性高血糖对大鼠心肌缺血/再灌注损伤(RMMI)缺血期和再灌注期的影响,并分析不同时期的高血糖与心肌损伤之间的关系。方法制备急性大鼠RMMI模型(缺血30 min,再灌注6 h),静脉输注高浓度的葡萄糖液,造成急性高血糖动物模型。将SD大鼠随机分为4组:假手术组(SHAM),生理盐水对照组(CON),缺血期高糖组(HGI)和再灌注期高糖组(HGR)。术中监测血糖水平,再灌注结束后检测心肌酶谱(CK,LDH)水平和心肌梗死(MI)面积。结果静脉输注高糖后大鼠血糖水平迅速而显著升高,造成缺血期和再灌注期急性高血糖。与CON组相比较,HGI组心肌酶谱水平显著升高,MI面积显著扩大[(46±9)%vs(38±6)%,P<0.05];而HGR组的心肌酶谱水平和MI面积与CON组相比无显著差异[(39±6)%vs(38±6)%]。结论缺血期急性高血糖可加重大鼠RMMI。 AIM To study the effects of hyperglycemia on different periods of reperfusion mediated myocardial injury（RMMI） in rats. METHODS Rats, subjected to 30 minutes of myocardial ischemia and 6 hours of reperfusion, randomly received one of the following treatments ： SHAM ; SON （ saline throughout ischemia and reperfusion period） ; HG1 （administration of 50% glucose by intravenous infusion during ischemia and saline during reperfusion） ; or HGR （saline during ischemia and 50% glucose during reperfusion）. Blood glucose levels were monitored throughout the experiments. Myocardial infarction（MI） size and serum myocardial enzymogram of rats were determined after the experiments. RESULTS Acute hyperglycemia during ischemia and reperfusion was successfully established after administration of high glucose intravenously. Hyperglycemia during ischemia rather than reperfusion significantly enlarged MI size and increased serum myocardial enzymogram following myocardial ischemia/reperfusion. CONCLUSION Hyperglycemia during ischemia rather than reperfusion significantly exacerbates RMMI, which can be used as a predictor of MI size and prognosis after myocardial ischemia and reperfusion.
作者 苏慧 孙新 黄晨 王晓明 张海锋 张昆如 高峰
机构地区 第四军医大学西京医院老年病二科 第四军医大学西京医院儿科 第四军医大学基础部生理学教研室
出处 《心脏杂志》 CAS 2007年第2期129-131,142,共4页 Chinese Heart Journal
关键词 高血糖 急性 心肌缺血/再灌注损伤 hyperglycemia, acute myocardial ischemia/reperfusion injury
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献7

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二级参考文献37

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共引文献30

同被引文献11

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心脏杂志
2007年 第2期

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