摘要
目的:研究生长抑素受体(somatostatin receptor,SSTR)在活动期溃疡性结肠炎(ulcerative colitis,UC)中的表达及其临床意义。方法:取36份活动期UC患者的结肠黏膜标本(结肠炎组)及30份体检者的结肠黏膜标本(对照组),采用免疫组织化学法检测两组SSTR的表达情况。结果:SSTR的表达主要定位于结肠黏膜的上皮细胞、纤维细胞、淋巴细胞和小血管的内皮细胞的细胞质中。SSTR在UC结肠黏膜中的阳性表达率为92%,明显高于对照组的73%(P<0.05)。中、重度UC患者结肠黏膜SSTR的阳性表达率均明显高于轻度UC患者(均为P<0.05)。便血明显(肉眼可见)的UC患者结肠黏膜SSTR的阳性表达率明显高于便血不明显(肉眼不可见,但潜血试验阳性)的UC患者(P<0.05)。结论:活动期UC患者结肠黏膜的SSTR的表达上调,其上调程度在病情较重或伴明显便血患者中更高。
Objective： To investigate the expression and clinical significance of somatostatin receptor （SSTR） in colonic mucosal tissues of patients with active ulcerative colitis（UC）. Methods： Expression of SSTR of colonic mucosa were tested by immunohistochemistry assay in 36 patients and 30 controls Results ： Expression of SSTR was mainly in the cytoplasm of epithelial cells, fiber cells, lymphocytes, and endothelial cells of small vessels, Positive expression rate of SSTR was 92% and 73% in the UC tissues and control tissues, respectively （P 〈0, 05 ）, Positive expression rate of SSTR was higher in moderate-severe UC than in mild UC （P 〈 0.05 ）, and that was higher in patients with obvious hematochezia （visible） than slight hematochezia （invisible, but positive occult blood test） （ P 〈 0, 05 ）. Conclusion ： Expression of SSTR is upregulation in the colonic mucosa of active UC, and the worse degree of the disease and hematochezia, the more upregulation of expression of SSTR.
出处
《新医学》
北大核心
2007年第4期220-222,共3页
Journal of New Medicine
基金
广东省卫生厅医学科研基金项目(A2004208)1
