摘要
目的探讨35岁及以下年轻宫颈癌患者的放疗疗效及影响预后的因素。方法回顾性分析112例年轻宫颈癌的临床特点，并依期别相同、肿瘤大小相近、病理类型相同、鳞癌病理分级相同、放疗方案相同配对抽取60岁及以上老年宫颈癌患者112例作对比研究。结果年轻组与老年组共224例，总5年生存率为58．5%。年轻组与老年组5年生存率分别为55．4%和61．6%，两组比较差异无统计学意义（P=0．485）。单因素分析肿瘤分期、肿瘤大小、病理分类、鳞癌分级、病理类型、近期疗效6种因素与年轻宫颈癌生存率的关系，其中放疗后肿瘤完全缓解、Ⅱb期患者、肿瘤≤4 cm疗效较好（P=0．000、0．000、0．000）。Cox回归模型对以上6种因素进行多因素分析，结果表明近期疗效和临床分期是影响年轻宫颈癌患者预后的独立因素（P=0．000、0．016）。结论年轻宫颈癌患者发病率逐年增加，构成比逐渐上升。排除肿瘤分期、肿瘤大小、病理分类、鳞癌分级、病理类型、近期疗效的影响后，年轻宫颈癌患者放疗疗效不比老年患者差。
Objective To study the clinical effect of radiation therapy and prognosis of carcinoma of uterine cervix in the young women under 35 years old. Methods From January 1985 to December 2000, the clinical characteristics of 112 young patients with carcinoma of uterine cervix were retrospectively analyzed. 112 patients older than 60 also having this cancer were matched for the study clinical stage, tumor size, pathologic type, pathologic grade of squamous cell carcinoma, the recent effects and tumor types. Results The overall 5-year survival rate for 224 patients including the young women group and older group was 58.5%. The 5-year survival rate of the young patients and the old patients was 55.4% and 61. 696 respeclively. Yet,there was no significant difference between these two groups （ P = 0.458 ）. Univariate analysis showed that among clinical stage, tumor size, pathologic type, pathologic grade of squamous cell carcinoma, the recent effects and tumor type, patients with stages Ⅱb, tumor size ≤4 cm and complete response after radiotherapy gave better survival（ P = 0.000,0.000,0.000）. Multivariate analysis by Cox regression model showed that recent effects and clinical stage were independent prognostic factors （P =0. 000,0. 016）. Conclusions The incidence of young patients are increasing year after year and the composing ratio of young patients are going up. Excluding the influence of clinical stage, tumor size, pathologic type, pathologic grade of squamous cell carcinoma, recent effects and tumor type, radiotherapic effect of young patients with cervical carcinoma was not and should not dwarved by the old patients （ P 〉 0.05 ）.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2007年第2期118-120,共3页
Chinese Journal of Radiation Oncology
关键词
宫颈肿瘤
放射疗法
年轻人
预后
Uterine neoplasms/radiotherapy
Youth
Prognosis
