摘要
目的了解影响肝硬化患者预后的主要指标。方法选择具有完整临床资料和随访结果的216例肝硬化患者进行回顾性分析。采用Kaplain-Meier法及Log-rank检验对50项指标进行单因素分析。再将单因素分析有意义的指标采用Cox回归模型进行多因素分析,筛选出影响预后的主要因素。结果多因素分析显示以下8项指标与肝硬化预后有显著相关性:总胆红素、肌酐、血浆凝血酶原时间、腹水、肝性脑病、年龄、天门冬酸氨基转移酶和碳酸氢根(P=0.000～0.018)。结论总胆红素、肌酐、血浆凝血酶原时间、腹水、肝性脑病、年龄、天门冬酸氨基转移酶和碳酸氢根是影响肝硬化预后的重要因素,建立预后评估模型时可考虑加入上述指标。
[Objective] To investigate the factors influencing the prognosis of hepatic cirrhosis. [Methods] A cohort of 216 patients with liver cirrhosis were retrospectively studied and followed up. 50 indexes were observed. Using Kaplan-Meier method and Log-rank test for univariate analysis. Using Cox proportional hazard regression for multivariate analysis. [Results] According to the multivariate Cox proportional hazard regression analysis, the factors that had significant influence on the prognosis of hepatic cirrhosis patients included： total bilirubin （TBIL）, creatinine （Cr）, prothrombin time （PT）, ascites （AS）, hepatic encephalopathy （HE）, age, aspartate aminotransferase （AST）, bicarbonate （HCO3） （P =0.000-0.018）. [Conclusions] The factors that contributed to the prognosis were： TBIL, Cr, PT, AS, HE, age, AST, HCO3. These indexes might be included in a model to predict the prognosis of hepatic cirrhosis patients.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2007年第6期718-721,724,共5页
China Journal of Modern Medicine
关键词
肝硬化
预后
多因素分析
hepatic cirrhosis
Prognosis
multivariate analysis
