摘要
目的研究谷草/谷丙转氨酶比值(AST/ALT)、乙型肝炎e抗原(HbeAg)与慢性乙型肝炎、肝炎后肝硬化、原发性肝癌的关系及临床意义。方法AST、ALT由贝克曼生化仪采用速率法检测,HBeAg由西班牙班珀斯变色龙全自动酶免分析仪采用ELISA方法检测。结果①肝炎后肝硬化的AST/ALT比值(1.67±0.72)与原发性肝癌组的(2.07±1.46)均高于慢性乙型肝炎组(0.84±0.46)(P<0.01);肝炎后肝硬化的HBeAg阳性率(16/49)与原发性肝癌组的(10/50)均低于慢性乙型肝炎组(30/51)(P<0.05,P<0.01);②慢性乙型肝炎组与肝炎后肝硬化组各组内HBeAg阳性的AST/ALT比值与HBeAg阴性的AST/ALT比值比较,无统计学意义(P>0.05)。结论随着HBV感染后疾病的进展,AST/ALT比值升高,HBeAg阳性率降低,提示肝细胞的破坏加剧可能与机体自身免疫功能有很大关系。
Objectives To investigate the relationship between ALT/AST ratio, HBeAg and the diseases after HBV infection. Methods AST and ALT were detected by kinetic method, HBeAg was detected by ELISA. Results The AST/ALT ratio in Hepatocirchosis （ 1.67 ± 0.72） and primary hepatic carcinoma（ PHC ） （2.07 ± 1.46） was higher than in chronic hepatitis B （CHB） （0.84 ± 0.46） （ P 〈 0.01 ） ; The HBeAg positive rate in hepatocirrhosis（16/49） and PHC（10/50） was lower than in CHB（30/51 ） （ P 〈0.05, P 〈0.01 ）. The AST/ALT ratio in HBeAg positive and HBeAg negtive was no statistics significance in CHB group and Hepateeirrhosis group（ P 〉0.05 ）. Conclusion With the diseases＇processing after HBV infection, the AST/ALT ratio was higher, HBeAg positive rate was lower and the liver cells were destroyed seriously,which was related with autoimmune response. ±
出处
《临床和实验医学杂志》
2007年第3期3-4,共2页
Journal of Clinical and Experimental Medicine
基金
青岛市自然科学基金资助项目(05-1-NS-70)
