摘要
[目的]研究胃炎平颗粒剂的提取工艺,为确定其疗效提供依据。[方法]采用正交设计L9(34),以浸膏得率和盐酸小檗碱含量为考察指标,考察加水量、药材的浸泡时间、提取时间和提取次数4个因素对提取的影响。[结果]经综合分析,最佳提取工艺为A2B3C1D3,加水量为处方药材量的10倍,药材浸泡时间为2h,提取3次,每次为1h。[结论]该项提取工艺条件稳定、合理且可降低生产成本,为本制剂大生产提供依据。
[Objective] To optimize the extraction process of Weiyanping granules. [Method]The orthogonal test method was adopted to explore the influences of 4 factors（quantity of water, soaking time,extraction time and times） on the yielding rate of berberine and dry paste rate. [Results]Analysis by synthesis, the optimum condition for extraction was A2 B3 C1 D3. The medicinal substances should be soaked in 10 times water for 2 hours and distilled for 3 times,with 1 hour each time. [Conclusion]The experiment result showed that the optimum extraction process condition was stable, reasonable and economical, which could be used to guide industrialized production.
出处
《浙江中医药大学学报》
CAS
2007年第2期211-212,共2页
Journal of Zhejiang Chinese Medical University
关键词
胃炎平颗粒剂
正交试验
提取工艺
浸膏得率
盐酸小檗碱
含量测定
Weiyanping granules
orthogonal test
extraction
dry paste rate
berberine hydroehloride
content determination
