摘要
[目的]观察氟西汀并逍遥丸治疗尿毒症维持性血液透析患者并发抑郁症的疗效与安全性。[方法]将40例并发抑郁症的尿毒症维持性血液透析患者随机分为两组,治疗组在卫生宣教的基础上加用氟西汀和逍遥丸,8周为1个疗程;对照组进行常规卫生宣教。分别在治疗后4周和8周采用抑郁自评量表(SDS)和血白蛋白、C反应蛋白等评价疗效,用副反应量表(TESS)评价安全性。[结果]治疗组SDS减分率明显高于对照组(P<0.05);治疗组总有效率为75.0%,对照组为30.0%,治疗组明显高于对照组(P<0.05);治疗组血白蛋白升高(P<0.05);氟西汀不良反应主要有早期一过性轻微胃肠道不适。[结论]氟西汀并逍遥丸对尿毒症维持性血液透析并发抑郁症的患者具有良好的疗效和安全性。
[Objective] To survey the rapeutic effectiveness and safety rate of fluoxetine and Xiaoyao pill in the treatment of depression complicated by sustained hemodialysis in patients with uremia. [Methods] 40 cases of depression complicated by sustained hemodialysis in patients with uremia were randomly divided into a trial group and a control group. On the basis of conventional health propaganda and education, the trial group was given fluoxetine and Xiaoyao pills for 8 consecutive weeks. The control group was subjected only to health propaganda and education. The therapeutic effectiveness was accessed with the Zung Self- Rating Depression Scale （SDS）, Albumin and CRP level in the serum while the safety rate was appraised with the Treatment Emergent Rating Scale （TESS）. [Results] The overall effective rates in the trial group and control group were 75% and 30% respectively （P〈0.05）. There was a much greater decrease in the score of SDS after the treatment in the trial group than that in patients of the control group （P〈0.05）. In the trial group there was an increase of Albumin. The major adverse reaction caused by fluoxetine was a slight gastrointestinal discomfort early in the course of treatment. [Conclusion] Fluoxetine was shown to he fairly effective and safe in the treatment of depression complicated by sustained hemodialysis in patients with uremia.
出处
《浙江中医药大学学报》
CAS
2007年第2期192-193,共2页
Journal of Zhejiang Chinese Medical University
关键词
氟西汀
逍遥丸
抑郁症
血液透析
fluoxetine
Xiaoyao pill
depression
hemodialysis
