摘要
目的:探讨α-干扰素治疗HPV隐性感染患者的最佳途径。方法:选取273例生殖道HPV隐性感染的女患者,随机分成3组:第1组应用α-干扰素皮下注射治疗,第2组应用α-干扰素生殖道靶位置注射治疗,第3组则采用前两种方式结合起来治疗,以上3组用药剂量均相同。实验前后利用PCR技术通过检测宫颈分泌物来确定HPV及主要分型。结果:治疗前各组HPV阳性率差异没有统计学意义(P>0.05),干预以后第3组的治疗效果明显优于前两组(P<0.05)。结论:皮下联合生殖道靶位置注射。α-干扰素的治疗效果显著,具有临床实际应用价值。
Objective： To investigate the best method of treating recessive HPV infection by α - interferon. Methods： 273 cases with recessive infection of HPV in genital tract were randomly divided into 3 groups ： the first group was treated withα- interferon through hy- podermic; the second group was injected withα - interferon through genital tract; and the third group was treated with α - interferon through hypodermic and the genital tract injection. The drug dosages were the same in the 3 groups. The method of PCR was used to detect HPV and its main subtype in cervix secretion before and after the intervention. Results： No statistical significance of the HPV positive rate in 3 groups was found before the intervention （ P 〉 0. 05）, the effect of the joint treatment group excelled the other two obviously after the intervention （ P 〈 0. 05 ） . Conclusion： α - interferon through hypodermic and the genital tract injection for the recessive HPV infection has very important clinical applied cost.
出处
《中国妇幼保健》
CAS
北大核心
2007年第10期1406-1407,共2页
Maternal and Child Health Care of China
基金
唐山市科技攻关项目(06134601D-35)
关键词
Α-干扰素
人乳头瘤状病毒
隐性感染
随机临床实验
α - interferon
Human papilloma virus
Recessive infection
Clinical randomized trial
