摘要
目的:总结胃肠道间质肿瘤(gastrointestinal stromal tumors,GIST)伴肝转移的诊断及治疗经验。方法:回顾性分析18例胃肠道间质肿瘤伴肝转移的临床资料。结果:胃肠道间质瘤伴肝转移18例,其中12例位于胃,2例位于十二指肠,4例位于结肠。临床表现主要为消化道出血(60%),腹部包块(25%),体检发现贫血(25%)。术前均行内窥镜、B超及CT检查,术前12例病理确诊(66.7%)。全组均行手术切除,无手术死亡和手术并发症,其中局部切除3例,12例扩大切除+肝转移灶切除+淋巴结清扫。6例患者术后服用甲磺酸伊马替尼(格列卫)辅助治疗。16例患者获得随访,1年生存率为88.9%,3年生存率为48.6%。结论:GIST伴肝转移术前确诊率低,综合分析有助于提高确诊率。手术切除为主的综合治疗是最可靠的治疗方法。
Objective： To evaluate diagnosis and treatment of gastrointestinal stromal tumors complicating with hepatic metastases. Methods：The clinical data of eighteen patients with hepatic metastases of GIST was analyzed retrospectively. Results：In all 18 patients,12 cases had the primary tumor in stomach, 2 cases in duodenum, 4 cases in colon. Clinical manifestation were alimentary tract hemorrhage （60%） , abdominal mass（25% ）, anemia （25%）. All the patients had endescopes, B-ultrasound and CT. Twelve cases had preoperative final diagnosis in pathology（66. 7% ）. All the patients had the primary focus exsected. All cases recovered without complications after operation. 1-year survival rates were 88. 9% and 3-year were 48. 6%. Sixteen patients recepted follow - up views, 6 cases had taken imatinib mesylate after surgery. Conclusion：GIST with hepatic metastases is hard to distinguish with other hepatic tumors. Aggregate analysis is helpful to preoperative diagnosis. Surgical resection with adjunctive therapies is the most effective way for it.
出处
《临床肿瘤学杂志》
CAS
2007年第3期191-193,共3页
Chinese Clinical Oncology
