摘要
本文用ＥＬＩＳＡ和放射免疫分析检测了５７例肾移植患者血清中可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）和肿瘤坏死因子（ＴＮＦ）水平。患者术前ｓＩＬ－２Ｒ和ＴＮＦ明显高于正常对照组，术后两者都逐渐下降，排斥反应时升高，排斥组与无排斥组差异显著。ＣｓＡ中毒组与无排斥组无明显差异，因此ｓＩＬ－２Ｒ和ＴＮＦ水平监测也可区别ＣｓＡ中毒和排斥反应。动态检测ｓＩＬ－２Ｒ和ＴＮＦ水平可作为肾移植后判断疗效和预后的重要观察指标。
Serum levels of soluble interleukin-2 receptor (sIL-2R) and tumor necrosis factor (TNF) were seperately measured by ELISA and radioimmunoassay in 57 patients after kidney transplantation.Their levels in patients before transplantation were significantly higher than those of healthy controls.After tranplantation sIL-2R and TNF levels gradually decreased, but they elevated when rejection occurred.Singnificant differences of sIL-2R and TNF levels were found between the patients with or without rejection, but there was no difference between those with CsA intoxication and without rejection.Dynanuc observation of serum sIL-2R and TNF levels is not only helpful to differentiate CsA intoxication from rejection,but also to monitor the therapeutic effect and prognos is kidney transplantation.
出处
《标记免疫分析与临床》
CAS
1996年第2期80-82,共3页
Labeled Immunoassays and Clinical Medicine
关键词
肾移植
SIL-2R
肿瘤坏死因子
Transplantation kidney Receptor, interleukin 2 Tumor necrosis factor Host vs graft reaction
