摘要
目的探讨原发性肝细胞癌(HCC)中E-钙黏附素(E-cadherin)与N-钙黏附素(N-cadherin)的表达情况以及两者表达的相关性,寻找它们与HCC转移的关系。方法采用免疫组化两步法检测46例HCC组织和10例正常肝组织中E-cadherin和N-cadherin的表达。结果46例HCC中E-cadherin呈低表达的有34例(73.9%),N-cadherin呈低表达的有30例(65.2%);10例正常肝组织中两种钙黏附素均呈高表达;E-cadherin和N-cadherin的表达皆与HCC分化程度有关(P<0.05),两者之间的表达强度呈正相关(Spearman秩相关系数r=0.579,P<0.01);对比转移倾向高危组和低危组,E-cadherin及N-cadhein的表达强度组间差别显著(Wilcoxon秩和检验P<0.05),高危组中表达强度更低。结论E-cadherin和N-cadherin在HCC中的表达较正常肝组织低;E-cadherin与N-cadherin呈正相关;两种黏附素的低表达提示HCC的低分化和高转移倾向。
Objective To explore the expression of E-eadherin and N-eadhefin in HCC and the relationship between E-cadherin and N-cadherin, and to seek their correlations to metastasis in HCC. Methods Expression of E-cadherin and N-cadherin was detected in 46 cases of HCC and 10 cases of normal liver specimens by EnVision HCC, 34 cases （73.9%） and 30 cases （65,2%） showed low expression of E-cadherin and N-cadherin, respectively, whereas all of the 10 cases （ 100% ） showed high expression of the both. The expression of E-casherin and N-cadherin was related with the malignant degree and metastasis potential （ P 〈 0.05）, and showed positive correlation between each other （ r = 0.579, P 〈 0.01 ）. Conclusions The expression levels of E-cadhefin and N-cadherin in HCC are lower than normal liver specimen. N- cadherin positively correlates with E-cadherin. The lower expression of E-cadherin and N-cadherin suggests poorly differentiated and higher potential of metasbasis.
出处
《诊断病理学杂志》
CSCD
2007年第1期60-64,共5页
Chinese Journal of Diagnostic Pathology
